Telgmann, Regina and von Kleist, Max and Huisinga, Wilhelm (2006) Software supported modelling in pharmacokinetics. In: Computational Life Sciences II: Second International Symposium, CompLife 2006, Cambridge, UK, September 27-29, 2006. Proceedings. Lecture Notes in Computer Science (LNCS), 4216/2006 . Springer Berlin / Heidelberg, pp. 216-225. ISBN 978-3-540-45767-1

Download (731kB)

Abstract

A powerful new software concept to physiologically based pharmacokinetic (PBPK) modelling of drug disposition is presented. It links the inherent modular understanding in pharmacology with orthogonal design principles from software engineering. This concept allows for flexible and user-friendly design of pharmacokinetic whole body models, data analysis, hypotheses testing or extrapolation. The typical structure of physiologically-based pharmacokinetic models is introduced. The resulting requirements from a modelling and software engineering point of view and its realizations in the software tool MEDICI-PK are described. Finally, an example in the context of drug-drug interaction studies is given, that demonstrates the advantage of defining a whole-body pharmacokinetic model in terms of the underlying physiological processes quite impressively: A system of 162 ODEs is automatically compiled based on the specification of 7 local physiological processes only.

Item Type:	Book Section
Additional Information:	The original publication is available at http://www.springerlink.com/content/n1449m8028925505/
Keywords:	Pharmacokinetics; Absorption; Distribution; Metabolism; Excretion; ADME; Mathematical Modelling; Physiologically Based Pharmacokinetics; PBPK; LNCS; Hamilton Institute.
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Computer Science Faculty of Science and Engineering > Mathematics and Statistics
Item ID:	1770
Identification Number:	https://doi.org/10.1007/11875741
Depositing User:	Hamilton Editor
Date Deposited:	11 Jan 2010 11:00
Publisher:	Springer Berlin / Heidelberg
Refereed:	No
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads