MURAL - Maynooth University Research Archive Library

    Membrane compartmentalisation of the ubiquitin system

    Rusilowicz-Jones, Emma V. and Brazel, Ailbhe J. and Frigenti, Francesca and Urbé, Sylvie and Clague, Michael J. (2022) Membrane compartmentalisation of the ubiquitin system. Seminars in Cell & Developmental Biology, 132. pp. 171-184. ISSN 1084-9521

    Download (2MB) | Preview

    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...

    Add this article to your Mendeley library


    We now have a comprehensive inventory of ubiquitin system components. Understanding of any system also needs an appreciation of how components are organised together. Quantitative proteomics has provided us with a census of their relative populations in several model cell types. Here, by examining large scale unbiased data sets, we seek to identify and map those components, which principally reside on the major organelles of the endomembrane system. We present the consensus distribution of > 50 ubiquitin modifying enzymes, E2s, E3s and DUBs, that possess transmembrane domains. This analysis reveals that the ER and endosomal compartments have a diverse cast of resident E3s, whilst the Golgi and mitochondria operate with a more restricted palette. We describe key functions of ubiquitylation that are specific to each compartment and relate this to their signature complement of ubiquitin modifying components.

    Item Type: Article
    Additional Information: Cite as: Emma V. Rusilowicz-Jones, Ailbhe J. Brazel, Francesca Frigenti, Sylvie Urbé, Michael J. Clague, Membrane compartmentalisation of the ubiquitin system, Seminars in Cell & Developmental Biology, Volume 132, 2022, Pages 171-184, ISSN 1084-9521,
    Keywords: ubiquitin system components; endomembrane system; Quantitative proteomics;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 17745
    Identification Number:
    Depositing User: Ailbhe Brazel
    Date Deposited: 26 Oct 2023 14:25
    Journal or Publication Title: Seminars in Cell & Developmental Biology
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

    Repository Staff Only(login required)

    View Item Item control page


    Downloads per month over past year

    Origin of downloads