Palm, Denise and Uzoni, Adriana and Simon, Frederick and Fischer, Matthias and Coogan, Andrew and Tucha, Oliver and Thome, Johannes and Faltraco, Frank (2021) Evolutionary conservations, changes of circadian rhythms and their effect on circadian disturbances and therapeutic approaches. Neuroscience & Biobehavioral Reviews, 128. pp. 21-34. ISSN 0149-7634

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Abstract

The circadian rhythm is essential for the interaction of all living organisms with their environments. Several processes, such as thermoregulation, metabolism, cognition and memory, are regulated by the internal clock. Disturbances in the circadian rhythm have been shown to lead to the development of neuropsychiatric disorders, including attention-deficit hyperactivity disorder (ADHD). Interestingly, the mechanism of the circadian rhythms has been conserved in many different species, and misalignment between circadian rhythms and the environment results in evolutionary regression and lifespan reduction. This review summarises the conserved mechanism of the internal clock and its major interspecies differences. In addition, it focuses on effects the circadian rhythm disturbances, especially in cases of ADHD, and describes the possibility of recombinant proteins generated by eukaryotic expression systems as therapeutic agents as well as CRISPR/Cas9 technology as a potential tool for research and therapy. The aim is to give an overview about the evolutionary conserved mechanism as well as the changes of the circadian clock. Furthermore, current knowledge about circadian rhythm disturbances and therapeutic approaches is discussed.

Item Type:	Article
Keywords:	Circadian rhythm; Evolutionary development of circadian genes; Attention-deficit hyperactivity disorder; Protein expression systems; CRISPR/Cas9;
Academic Unit:	Assisting Living & Learning,ALL institute Faculty of Science and Engineering > Psychology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	17864
Identification Number:	https://doi.org/10.1016/j.neubiorev.2021.06.007
Depositing User:	Dr. Andrew Coogan
Date Deposited:	21 Nov 2023 14:33
Journal or Publication Title:	Neuroscience & Biobehavioral Reviews
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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