Wrigley Kelly, Neil E. and Kenny, Grace and Cassidy, Féaron C. and Garcia‐Leon, Alejandro A. and De Barra, Conor and Mallon, Patrick W. G. and Hogan, Andrew E. and O'Shea, Donal (2022) Individuals with obesity who survive SARS‐CoV‐2 infection have preserved antigen‐specific T cell frequencies. Obesity, 30 (10). pp. 1927-1931. ISSN 1930-7381

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Abstract

Objective: Obesity is a major risk factor for severe disease in COVID-19, with increased hospitalization, intensive care unit admission, and mortality. This increased impact of COVID-19 in people with obesity (PWO) is likely driven, in part, by the well-described obesity-induced immune dysregulation. Obesity has also been associated with impaired immune memory in many settings, including weakened responses to hepatitis B, tetanus, rabies, and influenza vaccination. Recently, it was reported that PWO who have COVID-19 have reduced IgG antibody titers with defective neutralizing capabilities. However, it remains unknown whether PWO generate durable T cell immunity to SARS-CoV-2. Methods: This study investigated SARS-CoV-2-specific T cell responses in a cohort of 40 patients (n = 20 PWO and n = 20 matched control individuals) who had recovered from COVID-19. T cell (CD4+, CD8+) cytokine responses (IFNγ, TNFα) to SARS-CoV-2 peptide pools (spike, membrane) were determined using multicolor flow cytometry. Results: Circulating T cells specific for SARS-CoV-2 were readily detected in the total cohort. PWO displayed comparable levels of SARS-CoV-2 spike- and membrane-specific T cells, with both T cell subsets responding. Conclusions: These data indicate that PWO who survive COVID-19 generate robust and durable SARS-CoV-2-specific T cell immunity that is equivalent to that seen in those without obesity.

Item Type:	Article
Keywords:	Individuals; obesity; survive; SARS-CoV-2 infection; preserved; antigen-specific; T cell; frequencies;
Academic Unit:	Faculty of Science and Engineering > Research Institutes > Human Health Institute Faculty of Science and Engineering > Biology
Item ID:	18043
Identification Number:	https://doi.org/10.1002/oby.23526
Depositing User:	Andrew Hogan
Date Deposited:	16 Jan 2024 15:51
Journal or Publication Title:	Obesity
Publisher:	Wiley
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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