MURAL - Maynooth University Research Archive Library

    Susceptibility to the common cold virus is associated with day length.

    Wyse, Cathy A and Clarke, Ava C and Nordon, Enya A and Murtagh, Collette and Keogh, Alexandra A and Lopez, Lorna M (2022) Susceptibility to the common cold virus is associated with day length. iScience, 25 (8). p. 104789. ISSN 2589-0042

    Download (2MB) | Preview

    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...

    Add this article to your Mendeley library


    Seasonal rhythms are endogenous timing mechanisms that allow animals living at temperate latitudes to synchronize their physiology to the seasons. Human viral respiratory disease is prevalent in the winter at temperate latitudes, but the role of endogenous mechanisms in these recurring annual patterns is unclear. The Common Cold Project is a repository of data describing the experimental viral challenge of 1,337 participants across the seasons of the year. We report a secondary analysis of these data to investigate if susceptibility to the common cold is associated with day length. The majority of the participants (78%) showed signs of infection but only 32% developed clinical signs of disease, and the probability of infection was significantly higher in longer day lengths (summer), but the disease was more likely in short (winter) day lengths. The persistence of winter disease patterns in experimental conditions supports the role of endogenous seasonality in human susceptibility to viral infection.

    Item Type: Article
    Keywords: Cold virus; endogenous; Viral infection;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 18084
    Identification Number:
    Depositing User: Cathy Wyse
    Date Deposited: 26 Jan 2024 15:28
    Journal or Publication Title: iScience
    Publisher: i Science
    Refereed: Yes
    Funders: ERC Grant H2020ERC/950010/FAMILY/LOPEZ
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

    Repository Staff Only(login required)

    View Item Item control page


    Downloads per month over past year

    Origin of downloads