Wyse, Cathy A and Clarke, Ava C and Nordon, Enya A and Murtagh, Collette and Keogh, Alexandra A and Lopez, Lorna M (2022) Susceptibility to the common cold virus is associated with day length. iScience, 25 (8). p. 104789. ISSN 2589-0042

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Abstract

Seasonal rhythms are endogenous timing mechanisms that allow animals living at temperate latitudes to synchronize their physiology to the seasons. Human viral respiratory disease is prevalent in the winter at temperate latitudes, but the role of endogenous mechanisms in these recurring annual patterns is unclear. The Common Cold Project is a repository of data describing the experimental viral challenge of 1,337 participants across the seasons of the year. We report a secondary analysis of these data to investigate if susceptibility to the common cold is associated with day length. The majority of the participants (78%) showed signs of infection but only 32% developed clinical signs of disease, and the probability of infection was significantly higher in longer day lengths (summer), but the disease was more likely in short (winter) day lengths. The persistence of winter disease patterns in experimental conditions supports the role of endogenous seasonality in human susceptibility to viral infection.

Item Type:	Article
Keywords:	Cold virus; endogenous; Viral infection;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	18084
Identification Number:	https://doi.org/10.1016/j.isci
Depositing User:	Cathy Wyse
Date Deposited:	26 Jan 2024 15:28
Journal or Publication Title:	iScience
Publisher:	i Science
Refereed:	Yes
Funders:	ERC Grant H2020ERC/950010/FAMILY/LOPEZ
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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