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    The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS

    dos Santos, Claudia C. and Lopes-Pacheco, Miquéias and English, Karen and Rolandsson Enes, Sara and Krasnodembskaya, Anna and Rocco, Patricia R. M. (2024) The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS. Cells, 13 (2). p. 122. ISSN 2073-4409

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    Mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (EVs) have emerged as innovative therapeutic agents for the treatment of sepsis and acute respiratory distress syndrome (ARDS). Although their potential remains undisputed in pre-clinical models, this has yet to be translated to the clinic. In this review, we focused on the role of microRNAs contained in MSC-derived EVs, the EV microRNAome, and their potential contribution to therapeutic mechanisms of action. The evidence that miRNA transfer in MSC-derived EVs has a role in the overall therapeutic effects is compelling. However, several questions remain regarding how to reconcile the stochiometric issue of the low copy numbers of the miRNAs present in the EV particles, how different miRNAs delivered simultaneously interact with their targets within recipient cells, and the best miRNA or combination of miRNAs to use as therapy, potency markers, and biomarkers of efficacy in the clinic. Here, we offer a molecular genetics and systems biology perspective on the function of EV microRNAs, their contribution to mechanisms of action, and their therapeutic potential.

    Item Type: Article
    Keywords: acute lung injury; acute respiratory distress syndrome; extracellular vesicles; exosomes; mesenchymal stromal cells; microRNA; nano therapy; sepsis; systems biology;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 18571
    Identification Number:
    Depositing User: Karen English
    Date Deposited: 23 May 2024 10:49
    Journal or Publication Title: Cells
    Publisher: MDPI
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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