Dunbar, Hazel and Hawthorne, Ian J. and English, Karen
(2024)
Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms.
Molecular Therapy.
ISSN 1525-0016
Abstract
Sepsis is a complex condition leading to multiple organ failure including the development of acute respiratory distress syndrome
(ARDS) secondary to infection. The mortality rate of sepsis is 40%–60%,1 indicating an
unmet need for the development of novel
therapeutics for this condition. Mesenchymal stromal cells (MSCs) are known for
their immunomodulatory and cytoprotective
effects; however, their efficacy as a cellular
therapy for sepsis has been disappointing,
with less than �50% of patients responding
to treatment. Thus, strategies to enhance
MSC efficacy to increase the response rates
in patients are eagerly awaited.
| Item Type: |
Article
|
| Keywords: |
Carbon monoxide licensing; MSCs enhances; autophagy-mediated miRNA mechanisms; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
18682 |
| Identification Number: |
https://doi.org/10.1016/j.ymthe.2024.06.008 |
| Depositing User: |
Karen English
|
| Date Deposited: |
21 Jun 2024 09:12 |
| Journal or Publication Title: |
Molecular Therapy |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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