Dunbar, Hazel and Hawthorne, Ian J. and English, Karen (2024) Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms. Molecular Therapy. ISSN 1525-0016

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Abstract

Sepsis is a complex condition leading to multiple organ failure including the development of acute respiratory distress syndrome (ARDS) secondary to infection. The mortality rate of sepsis is 40%–60%,1 indicating an unmet need for the development of novel therapeutics for this condition. Mesenchymal stromal cells (MSCs) are known for their immunomodulatory and cytoprotective effects; however, their efficacy as a cellular therapy for sepsis has been disappointing, with less than �50% of patients responding to treatment. Thus, strategies to enhance MSC efficacy to increase the response rates in patients are eagerly awaited.

Item Type:	Article
Keywords:	Carbon monoxide licensing; MSCs enhances; autophagy-mediated miRNA mechanisms;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	18682
Identification Number:	https://doi.org/10.1016/j.ymthe.2024.06.008
Depositing User:	Karen English
Date Deposited:	21 Jun 2024 09:12
Journal or Publication Title:	Molecular Therapy
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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