Dunbar, Hazel and Hawthorne, Ian J. and English, Karen (2024) Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms. Molecular Therapy. ISSN 1525-0016
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Abstract
Sepsis is a complex condition leading to multiple organ failure including the development of acute respiratory distress syndrome (ARDS) secondary to infection. The mortality rate of sepsis is 40%–60%,1 indicating an unmet need for the development of novel therapeutics for this condition. Mesenchymal stromal cells (MSCs) are known for their immunomodulatory and cytoprotective effects; however, their efficacy as a cellular therapy for sepsis has been disappointing, with less than �50% of patients responding to treatment. Thus, strategies to enhance MSC efficacy to increase the response rates in patients are eagerly awaited.
Item Type: | Article |
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Keywords: | Carbon monoxide licensing; MSCs enhances; autophagy-mediated miRNA mechanisms; |
Academic Unit: | Faculty of Science and Engineering > Biology |
Item ID: | 18682 |
Identification Number: | https://doi.org/10.1016/j.ymthe.2024.06.008 |
Depositing User: | Karen English |
Date Deposited: | 21 Jun 2024 09:12 |
Journal or Publication Title: | Molecular Therapy |
Publisher: | Elsevier |
Refereed: | Yes |
URI: | |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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