More O'Ferrall, Lewis and Piatek, Magdalena and Twamley, Brendan and Kavanagh, Kevin and O'Connor, Christine and Griffith, Darren M. (2023) Synthesis, characterisation and antibacterial activity of novel Ga(iii) polypyridyl catecholate complexes. Dalton Transactions, 52 (34). pp. 11958-11964. ISSN 1477-9226

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Abstract

Ga(III) polypyridyl catecholate complexes of type [Ga(bipy)2(O,O)](NO3) or [Ga(phen)2(O,O)](NO3) respectively were readily synthesised on reaction of Ga(NO3)3 in methanol with 1 equivalent of catecholate ligand (2,3-DHBA, 3,4-DHBA, 2,3,4-THBA or CafA) and then 2 equivalents of either bipy or phen. The complexes were characterised in full including by X-ray crystallography, which established that the catecholate ligands coordinate the Ga(III) centres in a bidentate manner via the two deprotonated hydroxy groups. All Ga(III) complexes exhibited good in vitro antibacterial activity against the Gram-negative pathogenic bacteria Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. The complexes were inactive against the Gram-positive pathogenic bacteria Staphylococcus aureus including against a methicillin resistant Staphylococcus aureus strain (MRSA). [Ga(bipy)2(2,3-DHBA-2H)](NO3)·1.5H2O (1) was shown to be non toxic in vivo in larvae of Galleria mellonella at doses up to 2000 μg mL−1 and to offer protection at doses of 100 and 250 µg mL−1 at 48 and 96 h to larvae infected with P. aeruginosa.

Item Type:	Article
Keywords:	Biocompatibility; Chemical synthesis; Coliforms; Crystallography; E coli;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	18964
Identification Number:	https://doi.org/10.1039/d3dt01761c
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	03 Oct 2024 08:15
Journal or Publication Title:	Dalton Transactions
Publisher:	Royal Society of Chemistry
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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