One in three women globally will experience violence in their lifetime: violence against women (VAW) is a multi-layered human rights issue. This research internationalises the social movement perspective and employs a ‘political process’ approach to compare two social movement organisations (SMOs), the Argentinian SMO, Ni Una Menos (not one (woman) less) and the Irish SMO, ROSA (for Reproductive Rights, against Oppression, Sexism and Austerity). Both are currently engaged in mobilisations seeking radical social transformation, with a strong focus on eliminating VAW. Theoretically, pivotal moments in the struggle can be best understood through an analysis of the interaction of political opportunities, mobilising structures and framing processes. This research focuses on two national pivotal protests in Argentina and in Ireland, when these SMOs identified a political opportunity, and by utilising both traditional and digital mobilising structures shaped their ‘framing processes’ in response to VAW. This is achieved through the analysis of social media platforms utilised during these pivotal protests and interviews with members of both SMOs. This analysis makes a contribution to understanding how political opportunities shape mobilisations and rely on strong mobilising structures and resonant framing strategies in achieving concrete political outcomes.