D’Arcy, Kenneth and Schäfer, Tim and De Franco, Michele and Ricco, Raffaele and Gandin, Valentina and Sanz Miguel, Pablo J. and Montagner, Diego (2023) Unusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity. New Journal of Chemistry, 47 (39). pp. 18485-18491. ISSN 1144-0546

Preview

Download (628kB) | Preview

Abstract

The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.

Item Type:	Article
Keywords:	Anticancer properties; Chemistry; Chemistry; Multidisciplinary; Crystallography;
Academic Unit:	Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute
Item ID:	19134
Identification Number:	https://doi.org/10.1039/d3nj03186a
Depositing User:	Diego Montagner
Date Deposited:	31 Oct 2024 12:06
Journal or Publication Title:	New Journal of Chemistry
Publisher:	Royal Soc Chemistry
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads