MURAL - Maynooth University Research Archive Library

    Exploiting the potential of Insects for in vivo pathogenicity testing of Microbial pathogen

    Kavanagh, Kevin and Reeves, Emer P. (2004) Exploiting the potential of Insects for in vivo pathogenicity testing of Microbial pathogen. FEMS Microbiology Reviews, 28. pp. 101-112.

    [img] Download (210kB)

    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...

    Add this article to your Mendeley library


    Conventional assays for quantifying the virulence of microbial pathogens and mutants have traditionally relied upon the use of a range of mammalian species. A number of workers have demonstrated that insects can be used for evaluating microbial pathogenicity and provide results comparable to those that can be obtained with mammals since one component of the vertebrate immune system, the innate immune response, remains similar to that found in insects. Larvae of the Greater Wax Moth Galleria mellonella have been used to evaluate the virulence of a range of bacterial and fungal pathogens and a correlation with the virulence of these microbes in mice has been established. This review highlights the similarities of the vertebrate and insect innate immune responses to infection and identifies the potential use of insects for the in vivo evaluation of the microbial pathogenicity.

    Item Type: Article
    Keywords: Humoral immunity; Innate immune response; Insect; in vivo pathogenicity testing.
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 309
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 14 Jun 2006
    Journal or Publication Title: FEMS Microbiology Reviews
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

    Repository Staff Only(login required)

    View Item Item control page


    Downloads per month over past year

    Origin of downloads