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    GroEL and the maintenance of bacterial endosymbiosis

    Fares, Mario Ali and Moya, Andres and Barrio, Eladio (2004) GroEL and the maintenance of bacterial endosymbiosis. Trends in Genetics, 20 (9). pp. 413-416.

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    Many eukaryotic organisms have symbiotic associations with obligate intracellular bacteria. The clonal transmission of endosymbionts between host generations should lead to the irreversible fixation of slightly deleterious mutations in their non-recombinant genome by genetic drift. However, the stability of endosymbiosis indicates that some mechanism is involved in the amelioration of the effects of these mutations. We propose that the chaperone GroEL was involved in the acquisition of an endosymbiotic lifestyle not only by means of its over-production, as proposed by Moran, but also by its adaptive evolution mediated by positive selection to improve the interaction with the unstable endosymbiont proteome.

    Item Type: Article
    Keywords: Groel, bacterial endosymbiosis
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 322
    Depositing User: Dr. Mario Fares
    Date Deposited: 15 Jun 2006
    Journal or Publication Title: Trends in Genetics
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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