Fares, Mario Ali and Moya, Andres and Barrio, Eladio (2004) GroEL and the maintenance of bacterial endosymbiosis. Trends in Genetics, 20 (9). pp. 413-416.
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Abstract
Many eukaryotic organisms have symbiotic associations with obligate intracellular bacteria. The clonal transmission of endosymbionts between host generations should lead to the irreversible fixation of slightly deleterious mutations in their non-recombinant genome by genetic drift. However, the stability of endosymbiosis indicates that some mechanism is involved in the amelioration of the effects of these mutations. We propose that the chaperone GroEL was involved in the acquisition of an endosymbiotic lifestyle not only by means of its over-production, as proposed by Moran, but also by its adaptive evolution mediated by positive selection to improve the interaction with the unstable endosymbiont proteome.
Item Type: | Article |
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Keywords: | Groel, bacterial endosymbiosis |
Academic Unit: | Faculty of Science and Engineering > Biology |
Item ID: | 322 |
Depositing User: | Dr. Mario Fares |
Date Deposited: | 15 Jun 2006 |
Journal or Publication Title: | Trends in Genetics |
Publisher: | Elsevier |
Refereed: | Yes |
URI: | |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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