Kenna, Tony and Golden-Mason, Lucy and Norris, Suzanne and Hegarty, John E. and O'Farrelly, Cliona and Doherty, Derek G. (2004) Distinct subpopulations of gy T cells are present in normal and tumor-bearing human liv. Clinical Immunology, 113 (1). pp. 56-63.

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Abstract

gy T cells are thought to mediate immune responses at epithelial surfaces. We have quantified and characterized hepatic and peripheral blood gy T cells from 11 normal and 13 unresolved tumor-bearing human liver specimens. gy T cells are enriched in normal liver (6.6% of T cells) relative to matched blood (0.9%; P = 0.008). The majority express CD4CD8 phenotypes and many express CD56 and/or CD161. In vitro, hepatic gy T cells can be induced to kill tumor cell lines and release interferon-g, tumor necrosis factor-a, interleukin-2 and interleukin- 4. Analysis of Vgand Vy chain usage indicated that Vy3+ cells are expanded in normal livers (21.2% of gy T cells) compared to blood (0.5%; P = 0.001). Tumor-bearing livers had significant expansions and depletions of gy T cell subsets but normal cytolytic activity. This study identifies novel populations of liver T cells that may play a role in immunity against tumors.

Item Type:	Article
Keywords:	Tumor immunity; Liver; Human; gy T cells; Cytokines; Cytotoxicity
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	327
Depositing User:	Dr. Derek Doherty
Date Deposited:	23 Sep 2008
Journal or Publication Title:	Clinical Immunology
Publisher:	Elsevier
Refereed:	Yes
URI:	http://www.sciencedirect.com/science?_ob...
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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