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Lopez-Caamal, F., Oyarzún, Diego A., Moreno, J.A. and Kalamatianos, Dimitrios (2010) Control structure and limitations of biochemical networks. In: American Control Conference (ACC), 2010. IEEE, pp. 6668-6673. ISBN 9781424474257
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Abstract
Biochemical networks typically exhibit intricate
topologies that hinder their analysis with control-theoretic tools.
In this work we present a systematic methodology for the
identification of the control structure of a reaction network. The
method is based on a bandwidth reduction technique applied
to the incidence matrix of the network’s graph. In addition,
in the case of mass-action and stable networks we show that
it is possible to identify linear algebraic dependencies between
the time-domain integrals of some species’ concentrations. We
consider the extrinsic apoptosis pathway and an activation–
inhibition mechanism to illustrate the application of our results
| Item Type: | Book Section |
|---|---|
| Additional Information: | Preprint version of published paper. The definitive version of this paper is available at http://ieeexplore.ieee.org/Xplore/home.jsp DOI: 10.1109/NICRSP.1996.542760 |
| Keywords: | activation-inhibition mechanism , bandwidth reduction technique; biochemical networks; control structure; extrinsic apoptosis pathway; incidence matrix; linear algebraic; time-domain integrals; |
| Academic Unit: | Faculty of Science and Engineering > Research Institutes > Hamilton Institute |
| Item ID: | 3633 |
| Depositing User: | Dimitris Kalamatianos |
| Date Deposited: | 02 May 2012 15:29 |
| Publisher: | IEEE |
| Refereed: | No |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/3633 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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