Jarmuda, Stanislaw and O’Reilly, Niamh and Zaba, Ryszard and Jakubowicz, Oliwia and Szkaradkiewicz, Andrzej and Kavanagh, Kevin (2012) The potential role of Demodex folliculorum mites and bacteria in the induction of rosacea. Journal of Medical Microbiology, 61 (11 ). pp. 1504-1510. ISSN 0022-2615

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Abstract

Rosacea is a common dermatological condition that predominantly affects the central regions of the face. Rosacea affects up to 3% of the world’s population and a number of subtypes are recognized. Rosacea can be treated with a variety of antibiotics (e.g. tetracycline or metronidazole) yet no role for bacteria or microbes in its aetiology has been conclusively established. The density of Demodex mites in the skin of rosacea patients is higher than in controls, suggesting a possible role for these mites in the induction of this condition. In addition, Bacillus oleronius, known to be sensitive to the antibiotics used to treat rosacea, has been isolated from a Demodex mite from a patient with papulopustular rosacea and a potential role for this bacterium in the induction of rosacea has been proposed. Staphylococcus epidermidis has been isolated predominantly from the pustules of rosacea patients but not from unaffected skin and may be transported around the face by Demodex mites. These findings raise the possibility that rosacea is fundamentally a bacterial disease resulting from the over proliferation of Demodex mites living in skin damaged as a result of adverse weathering, age or the production of sebum with an altered fatty acid content. This review surveys the literature relating to the role of Demodex mites and their associated bacteria in the induction and persistence of rosacea and highlights possible therapeutic options.

Item Type:	Article
Additional Information:	Postprint version of original article. The definitve version of this article is available at doi: 10.1099/jmm.0.048090-0
Keywords:	Microbes; rosacea; bacteria; Demodex folliculorum mites;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	4092
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	23 Jan 2013 16:11
Journal or Publication Title:	Journal of Medical Microbiology
Publisher:	Society for General Microbiology
Refereed:	Yes
URI:	http://jmm.sgmjournals.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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