McCann, Malachy and Curran, Robert and Ben-Shoshan, Marcia and McKie, Vicky and Ali Tahir, Asif and Devereux, Michael and Kavanagh, Kevin and Creaven, Bernadette S. and Kellet, Andrew (2012) Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity. Dalton Transactions, 41 (21). 6516-6527 . ISSN 1477-9226

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Abstract

[Ag2(9-aca)2] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)2.3(CH3CN)0.7](9-aca) (3), [Ag6(imidH)4(9-aca)6(MeOH)2] (4), {[Ag(1-Me-imid)2]2[Ag4(9- aca)6]} (5), {[Ag(1-Bu-imid)2]2[Ag4(9-aca)6]} (6) and [Ag(apim)](9-aca)·H2O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4–6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(I) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.

Item Type:	Article
Additional Information:	The definitive version of this article is available at DOI: 10.1039/c2dt12166b
Keywords:	Silver(I) complexes; 9-anthracenecarboxylic acid; imidazoles; synthesis; structure; antimicrobial activity;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	4150
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	30 Jan 2013 16:56
Journal or Publication Title:	Dalton Transactions
Publisher:	Royal Society of Chemistry
Refereed:	Yes
URI:	http://pubs.rsc.org/en/Journals/JournalI...
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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