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    Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases

    Creaven, Bernadette S. and Duff, Brian and Egan, Denise A. and Kavanagh, Kevin and Rosair, Georgina and Reddy Thangellaa, Venkat and Walsh, Maureen (2010) Anticancer and antifungal activity of copper(II) complexes of quinolin-2(1H)-one-derived Schiff bases. Inorganica Chimica Acta, 363 (14). pp. 4048-4058. ISSN 0020-1693

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    The condensation of substituted aromatic aldehydes with 7-amino-4-methyl-quinolin-2(1H)-one (1) has lead to the isolation of quinolin-2(1H)-one derived Schiff bases (2–14). The copper(II) complexes (2a–14a) of the ligands were also prepared, and together with their corresponding free ligands were fully characterised by elemental analyses, spectral methods (IR, 1H and 13C NMR, AAS, UV–Vis), magnetic and conductance measurements. The bidentate ligands coordinated to the copper(II) ion through the deprotonated phenolic oxygen and the azomethine nitrogen of the ligands in almost all cases. X-ray crystal structures of two of the complexes, 5a and 8a, confirmed the bidentate coordination mode. All of the compounds were investigated for their antimicrobial activities against the fungus, Candida albicans, and against Gram-positive and Gram-negative bacteria. The compounds were found to have excellent anti-Candida activity but were inactive against Staphylococcus aureus and Escherichia coli. Selected compounds (2–8 and 2a–8a) were also screened for their in vitro anticancer potential using the human hepatic carcinoma cell line, Hep-G2. Several derivatives were shown to be active comparable to that of cisplatin.

    Item Type: Article
    Keywords: Quinolin-2(1H)-one; Schiff bases; Copper(II) complexes; Biological activity; X-ray structures;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 4170
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 31 Jan 2013 15:27
    Journal or Publication Title: Inorganica Chimica Acta
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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