O'Connor, David and Jones, Gary (2006) Chaperoning prions: the story unfolds. Biotech International (18). pp. 6-10.

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Abstract

Prions are infectious proteins that are responsible for a number of mammalian degenerative diseases. The discovery of prions in yeast has allowed detailed genetic analysis to be carried out to identify cellular factors involved in prion propagation. It is now clear that a complex relationship exists between molecular chaperones and prion propagation. Prions may actually have evolved to exploit the cell's chaperone machinery to ensure their own propagation.

Item Type:	Article
Keywords:	prions; prion propagation; chaperones; yeast;
Academic Unit:	Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID:	6020
Identification Number:	http://www.biotech-online.com
Depositing User:	Dr. Gary Jones
Date Deposited:	10 Apr 2015 16:12
Journal or Publication Title:	Biotech International
Publisher:	PanGlobal Media
Refereed:	No
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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