Maffioletti, Sara Martina and Noviello, Maddalena and English, Karen and Tedesco, Francesco Saverio
(2014)
Stem Cell Transplantation for Muscular Dystrophy:
The Challenge of Immune Response.
Boomed Research International (964010).
ISSN 2314-6141
Abstract
Treating muscle disorders poses several challenges to the rapidly evolving field of regenerative medicine. Considerable progress
has been made in isolating, characterizing, and expanding myogenic stem cells and, although we are now envisaging strategies to
generate very large numbers of transplantable cells (e.g., by differentiating induced pluripotent stemcells), limitations directly linked
to the interaction between transplanted cells and the host will continue to hamper a successful outcome. Among these limitations,
host inflammatory and immune responses challenge the critical phases after cell delivery, including engraftment, migration, and
differentiation. Therefore, it is key to study the mechanisms and dynamics that impair the efficacy of cell transplants in order to
develop strategies that can ultimately improve the outcome of allogeneic and autologous stemcell therapies, in particular for severe
disease such as muscular dystrophies. In this review we provide an overview of the main players and issues involved in this process
and discuss potential approaches that might be beneficial for future regenerative therapies of skeletal muscle.
| Item Type: |
Article
|
| Keywords: |
Stem Cell Transplantation; Muscular Dystrophy; Challenge; Immune Response; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6836 |
| Identification Number: |
https://doi.org/10.1155/2014/964010 |
| Depositing User: |
Karen English
|
| Date Deposited: |
19 Jan 2016 15:02 |
| Journal or Publication Title: |
Boomed Research International |
| Publisher: |
Hindawi Publishing Corporation |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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