English, Karen and French, Anna and Wood, Kathryn J.
(2010)
Mesenchymal Stromal Cells:
Facilitators of Successful Transplantation?
Cell Stem Cell, 7.
pp. 431-442.
ISSN 1875-9777
Abstract
Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory and reparative properties. Through
specific interactions with immune cells that participate in both innate and adaptive responses, MSCs exposed
to an inflammatory microenvironment can downregulate many immune effector functions. Clinical trials
focusing onMSCsto treat graft-versus-host disease (GvHD) and autoimmune diseases are underway. Current
analyses suggest that MSCs will improve cell and solid organ transplantation by ameliorating rejection and
possibly eliminating the requirement for prolonged regimens of conventional immunosuppressive drugs.
This review examines the in vitro and in vivo evidence for the clinical use of bone marrow derived MSCs.
| Item Type: |
Article
|
| Keywords: |
Mesenchymal Stromal Cells;
Facilitators; Successful Transplantation; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6837 |
| Identification Number: |
https://doi.org/10.1016/j.stem.2010.09.009 |
| Depositing User: |
Karen English
|
| Date Deposited: |
19 Jan 2016 15:52 |
| Journal or Publication Title: |
Cell Stem Cell |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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