Sharma, Visha and He, Chao and Sacca-Schaeffer, Julian and Brzozowski, Eric and Martin-Herranz, Daniel E. and Mendelowitz, Zelda and Fitzpatrick, David A. and O'Halloran, Damien M.
(2013)
Insight into the Family of Na+/Ca2+ Exchangers
of Caenorhabditis elegans.
Genetics, 195.
pp. 611-619.
ISSN 0016-6731
Abstract
Here we provide the first genome-wide in vivo analysis of the Na+/Ca2+ exchanger family in the model system Caenorhabditis
elegans. We source all members of this family within the Caenorhabditis genus and reconstruct their phylogeny across
humans and Drosophila melanogaster. Next, we provide a description of the expression pattern for each exchanger gene in C. elegans,
revealing a wide expression in a number of tissues and cell types including sensory neurons, interneurons, motor neurons, muscle cells,
and intestinal tissue. Finally, we conduct a series of behavioral and functional analyses through mutant characterization in C. elegans.
From these data we demonstrate that, similar to mammalian systems, the expression of Na+/Ca2+ exchangers in C. elegans is skewed
toward excitable cells, and we propose that C. elegans may be an ideal model system for the study of Na+/Ca2+ exchangers.
| Item Type: |
Article
|
| Additional Information: |
The definitive published version of this article is available at DOI: 10.1534/genetics.113.153106 |
| Keywords: |
Caenorhabditis elegans; comparative phylogeny; exchanger proteins; gene expression pattern; sodium calcium exchanger; sodium calcium potassium exchanger; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
6871 |
| Identification Number: |
https://doi.org/10.1534/genetics.113.153106 |
| Depositing User: |
David Fitzpatrick
|
| Date Deposited: |
20 Jan 2016 11:44 |
| Journal or Publication Title: |
Genetics |
| Publisher: |
Genetics Society of America |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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