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    Insight into the Family of Na+/Ca2+ Exchangers of Caenorhabditis elegans

    Sharma, Visha and He, Chao and Sacca-Schaeffer, Julian and Brzozowski, Eric and Martin-Herranz, Daniel E. and Mendelowitz, Zelda and Fitzpatrick, David A. and O'Halloran, Damien M. (2013) Insight into the Family of Na+/Ca2+ Exchangers of Caenorhabditis elegans. Genetics, 195. pp. 611-619. ISSN 0016-6731

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    Here we provide the first genome-wide in vivo analysis of the Na+/Ca2+ exchanger family in the model system Caenorhabditis elegans. We source all members of this family within the Caenorhabditis genus and reconstruct their phylogeny across humans and Drosophila melanogaster. Next, we provide a description of the expression pattern for each exchanger gene in C. elegans, revealing a wide expression in a number of tissues and cell types including sensory neurons, interneurons, motor neurons, muscle cells, and intestinal tissue. Finally, we conduct a series of behavioral and functional analyses through mutant characterization in C. elegans. From these data we demonstrate that, similar to mammalian systems, the expression of Na+/Ca2+ exchangers in C. elegans is skewed toward excitable cells, and we propose that C. elegans may be an ideal model system for the study of Na+/Ca2+ exchangers.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1534/genetics.113.153106
    Keywords: Caenorhabditis elegans; comparative phylogeny; exchanger proteins; gene expression pattern; sodium calcium exchanger; sodium calcium potassium exchanger;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6871
    Identification Number:
    Depositing User: David Fitzpatrick
    Date Deposited: 20 Jan 2016 11:44
    Journal or Publication Title: Genetics
    Publisher: Genetics Society of America
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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