Smith, Alanna and Rowan, Raymond and McCann, Malachy and Kavanagh, Kevin (2012) Exposure of Staphylococcus aureus to silver(I) induces a short term protective response. Biometals, 25 (3). pp. 611-616. ISSN 0966-0844

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Abstract

The Ag(I) ion has well established antibacterial and antifungal properties. Exposure of Staphylococcus aureus to MIC80 AgNO3 (3 lg/ml) lead to an increase in the activity of superoxide dismutase, glutathione reductase and catalase at 30 min but activity declined by 60 min. In addition, exposure of cells to this metal ion for 1 h lead to increased expression of a number of proteins such as elongation factors Ts, Tu and G, fructose-bisphosphate aldolase and triosephosphate isomerase but their expression declined following 4 h exposure. ATP binding cassette transporter protein and oligoendopeptidase F showed increased expression at 4 h. While Ag(I) is a potent antimicrobial agent this work demonstrates that S. aureus can mount a short-term protective response to exposure to the metal ion but that this is eventually overcome.

Item Type:	Article
Additional Information:	The definitive published version of this article is available at DOI: 10.1007/s10534-012-9549-3
Keywords:	Antimicrobial; Silver(I); Staphylococcus; Proteomics; Oxidative stress;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	6889
Identification Number:	https://doi.org/10.1007/s10534-012-9549-3
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	20 Jan 2016 13:21
Journal or Publication Title:	Biometals
Publisher:	Springer Verlag
Refereed:	Yes
URI:	http://link.springer.com/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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