McGinley, John and McCann, Malachy and Ni, Kaijie and Tallon, Theresa M. and Kavanagh, Kevin and Devereux, Michael and Ma, Xiaomei and McKee, Vickie
(2013)
Imidazole Schiff base ligands: Synthesis, coordination complexes and
biological activities.
Polyhedron, 55.
pp. 169-178.
ISSN 0277-5387
Abstract
1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldeh yde and a selection of imidazole aldehydes
and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal
structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde
ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic,
in vivo , towards Galleria mellonella . Although the free ligands and the Cu(II) and Zn(II) complexes are inactive,
in vitro , against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate
anti-bacterial activity and good anti-fungal activity.
Item Type: |
Article
|
Additional Information: |
The definitive published version of this article is available at DOI: 10.1016/j.poly.2013.03.023 |
Keywords: |
Imidazoles; Schiff bases; Metal complexes; X-ray; Antimicrobial; Galleria mellonella; |
Academic Unit: |
Faculty of Science and Engineering > Biology |
Item ID: |
6891 |
Identification Number: |
https://doi.org/10.1016/j.poly.2013.03.023 |
Depositing User: |
Dr. Kevin Kavanagh
|
Date Deposited: |
20 Jan 2016 13:21 |
Journal or Publication Title: |
Polyhedron |
Publisher: |
Elsevier |
Refereed: |
Yes |
URI: |
|
Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
Repository Staff Only(login required)
|
Item control page |
Downloads per month over past year
Origin of downloads