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    Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities

    McGinley, John and McCann, Malachy and Ni, Kaijie and Tallon, Theresa M. and Kavanagh, Kevin and Devereux, Michael and Ma, Xiaomei and McKee, Vickie (2013) Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities. Polyhedron, 55. pp. 169-178. ISSN 0277-5387

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    1-(3-Aminopropyl)imidazole (Apim) reacts with salicylaldeh yde and a selection of imidazole aldehydes and the resulting Schiff base ligands readily coordinate to Zn(II), Cu(II) and Ag(I) centres. X-ray crystal structures were obtained for two of the free ligands and also the Ag(I) complex of the Apim-salicylaldehyde ligand. Encouragingly, all of free ligands and most of their metal complexes are relatively non-toxic, in vivo , towards Galleria mellonella . Although the free ligands and the Cu(II) and Zn(II) complexes are inactive, in vitro , against a selection of microbial pathogens, most of the Ag(I) complexes exhibit moderate anti-bacterial activity and good anti-fungal activity.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/j.poly.2013.03.023
    Keywords: Imidazoles; Schiff bases; Metal complexes; X-ray; Antimicrobial; Galleria mellonella;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 6891
    Identification Number:
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 20 Jan 2016 13:21
    Journal or Publication Title: Polyhedron
    Publisher: Elsevier
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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