Walsh, Fiona and Rogers, Thomas R.
(2012)
Comparison of plasmid-mediated quinolone
resistance and extended-spectrum b-lactamases
in third-generation cephalosporin-resistant
Enterobacteriaceae from four Irish hospitals.
Journal of Medical Microbiology, 61.
pp. 142-147.
ISSN 0022-2615
Abstract
In this study, the frequency of extended-spectrum b-lactamases (ESBL) and plasmid-mediated
quinolone resistance (PMQR) mechanisms were investigated in 206 clinical isolates of third generation
cephalosporin (3GC)-resistant Enterobacteriaceae in four hospitals in the Republic of
Ireland. blaCTX-M-15 was the predominant ESBL gene. Of these 3GC resistant isolates, 54% were
also resistant to ciprofloxacin. Investigation of the PMQR mechanisms revealed that the aac(69)
Ib-cr gene predominated in fluoroquinolone-resistant (FQR) strains of Escherichia coli and
Klebsiella pneumoniae, while the qnrA gene predominated in the FQR strains of Enterobacter.
The blaCTX-M-15 gene was frequently identified with the aac(69)Ib-cr gene but was not always on
the same plasmid. The prevalence of the blaCTX-M-15 gene appeared to be hospital-dependent.
The epidemiology of both ESBL-producing and PMQR strains within the four hospitals indicated
that their prevalence is not due to the spread of these resistance genes between isolates from
different hospitals.
Item Type: |
Article
|
Additional Information: |
The definitive published version of this article is available at DOI: 10.1099/jmm.0.035246-0 |
Keywords: |
plasmid-mediated quinolone
resistance; extended-spectrum b-lactamases;
third-generation; cephalosporin-resistant
Enterobacteriaceae; |
Academic Unit: |
Faculty of Science and Engineering > Biology |
Item ID: |
6949 |
Identification Number: |
https://doi.org/10.1099/jmm.0.035246-0 |
Depositing User: |
Fiona Walsh
|
Date Deposited: |
04 Feb 2016 11:02 |
Journal or Publication Title: |
Journal of Medical Microbiology |
Publisher: |
Society for General Microbiology |
Refereed: |
Yes |
Funders: |
Health Research Board (HRB) |
URI: |
|
Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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