Oyarzún, Diego A. and Bramhall, Jo L. and Lopez-Caamal, Fernando and Richards, Frances M. and Jodrell, Duncan I. and Krippendorff, Ben-Fillippo (2014) The EGFR demonstrates linear signal transmission. Integrative Biology, 6 (8). pp. 736-742. ISSN 1757-9694

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Abstract

Cells sense information encoded in extracellular ligand concentrations and process it using intracellular signalling cascades. Using mathematical modelling and high-throughput imaging of individual cells, we studied how a transient extracellular growth factor signal is sensed by the epidermal growth factor receptor system, processed by downstream signalling, and transmitted to the nucleus. We found that transient epidermal growth factor signals are linearly translated into an activated epidermal growth factor receptor integrated over time. This allows us to generate a simplified model of receptor signaling where the receptor acts as a perfect sensor of extracellular information, while the nonlinear input–output relationship of EGF-EGFR triggered signalling is a consequence of the downstream MAPK cascade alone.

Item Type:	Article
Additional Information:	The definitive published version of this article is available at DOI: 10.1039/c4ib00062e
Keywords:	EGFR; linear signal transmission; epidermal growth factor receptor system;
Academic Unit:	Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID:	6962
Identification Number:	https://doi.org/10.1039/c4ib00062e
Depositing User:	Hamilton Editor
Date Deposited:	05 Feb 2016 17:02
Journal or Publication Title:	Integrative Biology
Publisher:	Royal Society of Chemistry
Refereed:	Yes
Funders:	National Biophotonics and Imaging Platform, Ireland, Cancer Research UK
URI:	http://pubs.rsc.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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