Wren, A.W. and Coughlan, A. and Smale, K.E. and Misture, S.T. and Mahon, Bernard P. and Clarkin, O.M. and Towler, M.R. (2012) Fabrication of CaO–NaO–SiO 2 /TiO 2 scaffolds for surgical applications. Journal of Materials Science: Materials in Medicine, 23 (12). pp. 2881-2891. ISSN 1573-4838

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Abstract

A series of titanium (Ti) based glasses were formulated (0.62 SiO 2 –0.14 Na 2 O–0.24 CaO, with 0.05 mol% TiO 2 substitutions for SiO 2 ) to develop glass/cera- mic scaffolds for bone augmentation. Glasses were initially characterised using X-ray diffraction (XRD) and particle size analysis, where the starting materials were amorphous with 4.5 l m particles. Hot stage microscopy and high temperature XRD were used to determine the sintering temperature ( * 700 ° C) and any crystalline phases present in this region (Na 2 Ca 3 Si 6 O 16 , combeite and quartz). Hardness testing revealed that the Ti-free control ( ScC — 2.4 GPa) had a significantly lower hardness than the Ti-containing materials ( Sc1 and Sc2 * 6.6 GPa). Optical microscopy determined pore sizes ranging from 544 to 955 l m. X-ray microtomography calculated porosity from 87 to 93 % and surface area measurements ranging from 2.5 to 3.3 SA/mm 3 . Cytotoxicity testing (using mesen- chymal stem cells) revealed that all materials encouraged cell proliferation, particularly the higher Ti-containing scaffolds over 24–72 h.

Item Type:	Article
Keywords:	Fabrication; scaffolds; surgical applications;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID:	7112
Identification Number:	https://doi.org/10.1007/s10856-012-4746-8
Depositing User:	Bernard Mahon
Date Deposited:	19 May 2016 10:20
Journal or Publication Title:	Journal of Materials Science: Materials in Medicine
Publisher:	Springer Verlag
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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