Coughlan, A. and Scanlon, K. and Mahon, Bernard P. and Towler, M.R.
(2010)
Zinc and silver glass polyalkenoate cements:
An evaluation of their antibacterial nature.
Bio-Medical Materials and Engineering, 20 (2).
pp. 99-106.
ISSN 0959-2989
Abstract
A biofilm is an accumulation of micro-organisms and their extracellular products forming a structured community
on a surface. Biofilm formation on medical devices has severe health consequences as bacteria growing in this lifestyle are
tolerant to both host defence mechanisms and antibiotic therapies. However, silver and zinc ions inhibit the attachment and
proliferation of immature biofilms. The objective of this study is to evaluate whether silver and zinc ions eluted from novel
glass polyalkenoate cement (GPC) coatings have the ability to inhibit Methicillin-resistant Staphylococcus aureus (MRSA)
in vivo. A silver and zinc-containing GPC coating was synthesised, deposited onto Ti6Al4V discs and placed in a specified
amount of analytical water for 1, 7 and 30 days. The resulting elutes were collected and Atomic absorption spectroscopy was
used to measure ion release. The elutes were injected into Galleria mellonella larvae infected with MRSA and the antibacterial
properties of these elutes were evaluated in vivo. The majority of the zinc and silver ions were released within the first 24 h;
this corresponded with the greatest degree of protection observed in infected larvae. Results were compared to a conventional
in vitro model where identical elutes were incubated with MRSA on nutrient agar. These results were consistent with those
observed in the larval model, demonstrating a reduction in bacterial viability when co-cultured with elutes for 2 h. This work
confirms the promise of the Galleria mellonella as a model for the assessment of antimicrobial agents and demonstrates the
capacity of novel silver and zinc-containing GPCs to retard the colonisation of MRSA.
| Item Type: |
Article
|
| Keywords: |
Glass polyalkenoate cement; antibacterial; zinc; silver; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7164 |
| Identification Number: |
https://doi.org/10.3233/BME-2010-0620 |
| Depositing User: |
Bernard Mahon
|
| Date Deposited: |
06 Jul 2016 09:56 |
| Journal or Publication Title: |
Bio-Medical Materials and Engineering |
| Publisher: |
IOS Press |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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