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    Genome Sequence of the Pea Aphid Acyrthosiphon pisum

    Gibbs, Richard A. and Kovar, Christie and Fowler, Gerald R. and Nazareth, Lynne V. and Atsushi, Nakabachi and Worley, Kim C. and Tagu, Denis and Richards, Stephen and Gabaldon, Toni and Rispe, Claude and Quesneville, Hadi and Douglas, Angela and Shigenobu, Shuji and Moran, Nancy and Barribeau, Seth M. and Gerardo, Nichole M. and Ghanim, Murad and Chang, Chun-che and Davis, Gregory K. and Rider Jr., Stanley Dean and Walsh, Thomas K. and Brisson, Jennifer A. and Miura, Toru and Srinivasan, Dayalan and Willson, Alex C.C. and Jaubert-Possamai, Stephanie and Robertson, Hugh M. and Field, Linda M. and Jander, Georg and Carolan, James C. and Edwards, Owain R. and Tamborindeguy, Cecilia and Martinez-Torres, David and Dale, Richard P. and Charles, Hubert (2010) Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology, 8 (2). e1000313. ISSN 1545-7885

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    Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.

    Item Type: Article
    Additional Information: The authors list above includes only Principle Investigator and Analysis Group Leaders, and not the entire membership of the International Aphid Genomics Consortium. Please cite this article as: The International Aphid Genomics Consortium (2010) Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biol 8(2): e1000313. doi:10.1371/ journal.pbio.1000313
    Keywords: International Aphid Genomics Consortium; Pea Ahpid; Acyrthosiphon pisum; Genome sequence;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7167
    Depositing User: James Carolan
    Date Deposited: 06 Jul 2016 15:32
    Journal or Publication Title: PLoS Biology
    Publisher: Public Library of Science
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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