Nic An Ultaigh, Sinéad and Carolan, James C. and Britton, Collette and Murray, Linda and Ryan, Michael F.
(2009)
A cathepsin L-like protease from Strongylus vulgaris: An orthologue
of Caenorhabditis elegans CPL-1.
Experimental Parasitology, 121 (4).
pp. 293-299.
ISSN 0014-4894
Abstract
Cathespin L-like proteases (CPLs), characterized from a wide range of helminths, are significant in helminth
biology. For example, in Caenorhabditis elegans CPL is essential for embryogenesis. Here, we report
a cathepsin L-like gene from three species of strongyles that parasitize the horse, and describe the isolation
of a cpl gene (Sv-cpl-1) from Strongylus vulgaris, the first such from equine strongyles. It encodes a
protein of 354 amino acids with high similarity to other parasitic Strongylida (90–91%), and C. elegans
CPL-1 (87%), a member of the same Clade. As S. vulgaris cpl-1 rescued the embryonic lethal phenotype
of the C. elegans cpl-1 mutant, these genes may be orthologues, sharing the same function in each species.
Targeting Sv-CPL-1 might enable novel control strategies by decreasing parasite development and
transmission.
| Item Type: |
Article
|
| Additional Information: |
The definitive version of this article is available at Ultaigh SN, Carolan JC, Britton C, Murray L, Ryan MF. 2009, 'A cathepsin L-like protease from Strongylus vulgaris: an orthologue of Caenorhabditis elegans CPL-1', Experimental Parasitology, vol. 121, no.4 pp. 293-299. DOI: 10.1016/j.exppara.2008.11.002 |
| Keywords: |
Nematode; Equine parasite; Strongylus vulgaris; Cathepsin L gene; C. elegans mutant rescue; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7169 |
| Identification Number: |
https://doi.org/10.1016/j.exppara.2008.11.002 |
| Depositing User: |
James Carolan
|
| Date Deposited: |
07 Jul 2016 11:43 |
| Journal or Publication Title: |
Experimental Parasitology |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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