MURAL - Maynooth University Research Archive Library

    The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

    Moynagh, Paul N. (2009) The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends in Immunology, 30 (1). pp. 33-42. ISSN 1471-4906

    Download (1MB) | Preview

    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...

    Add this article to your Mendeley library


    This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pellino family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of Pellino proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of Pellino biology begins to fill some long-standing voids in our understanding of TLR signalling.

    Item Type: Article
    Additional Information: The definitive published version of this article is available at DOI: 10.1016/
    Keywords: Pellino family; IRAK E3 ligases; innate immune signalling; toll-like receptor pathways;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7199
    Identification Number:
    Depositing User: Professor Paul Moynagh
    Date Deposited: 18 Jul 2016 15:57
    Journal or Publication Title: Trends in Immunology
    Publisher: Elsevier
    Refereed: Yes
    Funders: Science Foundation Ireland (SFI)
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

    Repository Staff Only(login required)

    View Item Item control page


    Downloads per month over past year

    Origin of downloads