Johnson, Gemma and Ferrini, Arianna and Dolan, Stephen K. and Nolan, Tania and Agrawal, Samir and Doyle, Sean and Bustin, Stephen A.
(2014)
Biomarkers for invasive aspergillosis: the
challenges continue.
Biomarkers in Medicine, 8 (3).
pp. 429-451.
ISSN 1752-0363
Abstract
The incidence of invasive aspergillosis (IA), an opportunistic infection in immunocompromised
individuals, is rising, but its early diagnosis remains challenging and
treatment options are limited. Hence there is an urgent need to improve existing
diagnostic procedures as well as develop novel approaches. The clinical usefulness
of galactomannan and β-d-glucan, widely used assays detecting cell-wall antigens
of Aspergillus, is unclear and depends on clinicians’ awareness of their practical
limitations. This leaves room for new methods that utilize genomic, proteomic and
metabolomics approaches as well as novel detection procedures, for example pointof-
care lateral-flow devices. Each of these strategies has its own limitations and it is
likely that a combination of methods will be required to achieve optimal performance
for the diagnosis of IA and subsequent appropriate patient management.
| Item Type: |
Article
|
| Additional Information: |
This is the postprint version of the published article, which is available at DOI 10.2217/bmm.13.129. |
| Keywords: |
antifungal agents; Aspergillus; β-d-glucan; conidium; ELISA; fungal infection; galactomannan; immunosuppression; invasive aspergillosis; matrix-assisted laser desorption ionization-TOF; quantitative PCR; siderophore; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7389 |
| Identification Number: |
https://doi.org/10.2217/bmm.13.129 |
| Depositing User: |
Dr. Sean Doyle
|
| Date Deposited: |
26 Aug 2016 14:48 |
| Journal or Publication Title: |
Biomarkers in Medicine |
| Publisher: |
Future Medicine Ltd |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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