Rowan, Raymond and Tallon, Theresa M. and Sheahan, Anita and Curran, Robert and McCann, Malachy and Kavanagh, Kevin and Devereux, Michael and McKee, Vickie (2006) 'Silver bullets' in antimicrobial chemotherapy: Synthesis, characterisation and biological screening of some new Ag(I)-containing imidazole complexes. Polyhedron, 25. pp. 1771-1778. ISSN 0277-5387

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Abstract

Simple synthetic routes are given to the Ag(I) complexes, [Ag2(imH)4](salH)2 (imH = imidazole; salH2 = salicylic acid), [Ag(MeNO2imH)2]ClO4 · nH2O (MeNO2imH = 2-methyl-5-nitroimidazole; n = 1, 3), [Ag(NO2im)] (NO2imH = 5-nitroimidazole) and [Ag(apim)]ClO4 (apim = 1-(3-aminopropyl)imidazole). X-ray crystal structures of [Ag2(imH)4](salH)2, [Ag(MeNO2imH)2]ClO4 · H2O and [Ag(apim)]ClO4 were obtained. The new Ag(I) complexes and related known Ag(I) imidazolates were screened for their growth inhibitory effects (in vitro) against the pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli and also the fungal pathogen Candida albicans. [Ag2(imH)4](salH)2, in comparison to the prescription drug silver sulfadiazine, had significantly better anti-bacterial qualities, whilst against the fungus C. albicans it was 47 times more potent than the marketed drug ketoconazole.

Item Type:	Article
Keywords:	Imidazoles; X-ray structures; Silver(I); Anti-fungal; Anti-bacterial;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	7575
Identification Number:	https://doi.org/10.1016/j.poly.2005.11.021
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	26 Oct 2016 13:48
Journal or Publication Title:	Polyhedron
Publisher:	Elsevier
Refereed:	Yes
Funders:	Higher Education Authority (HEA), Kildare County Council
URI:	http://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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