Fullam, Anthony
(2013)
The
role
of
the
DEAD
box
Helicase
DDX3X
in
Anti-‐Viral
Signalling
Pathways
Mediated
by
the
Kinase
IKKα.
PhD thesis, National University of Ireland Maynooth.
Abstract
The human DEAD-box RNA helicase DDX3X has previously been shown to be
involved in innate immune signalling in pathways mediated by IKKε and TBK1. In
this work we show that DDX3X is also involved in pathways independent of these
kinases, and functions by interacting with two related kinases IKKα and NIK.
DDX3X enhances the activation of IKKα and subsequently, augments the activation
of pathways that IKKα regulates. We show that DDX3 is involved in two important
signalling pathways that are mediated by IKKα – the alternative NF-κB pathway and
the TLR7 signalling pathway to type I IFN induction. We propose that DDX3X acts
as a scaffolding protein that brings together IKKα and its substrates.
| Item Type: |
Thesis
(PhD)
|
| Keywords: |
DEAD box Helicase DDX3X; Anti-Viral Signalling Pathways; Mediated; Kinase IKKα; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
7723 |
| Depositing User: |
IR eTheses
|
| Date Deposited: |
11 Jan 2017 15:21 |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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