Algay, Virginie and O'Sullivan, Justine and Heaney, Frances
(2014)
C-3β-Tethered Functional Cholesterol Conjugates by Nitrile Oxide Alkyne Cycloaddition (NOAC).
European Journal of Organic Chemistry, 2014 (12).
pp. 2522-2532.
ISSN 1434-193X
Abstract
Covalent cholesterol conjugates have been prepared by isoxazole-generating [3+2] nitrile oxide alkyne cycloaddition (NOAC) chemistry. Steroidal building blocks functionalised with either an alkyne or a nitrile oxide precursor were evaluated. The reaction has been demonstrated for the tethering to cholesterol of groups capable of bioreporting, and for the formation of cholesterol–biomolecule conjugates.
Item Type: |
Article
|
Keywords: |
Steroids; Lipids; Cycloaddition; Alkynes; Heterocycles; Conjugation; |
Academic Unit: |
Faculty of Science and Engineering > Chemistry |
Item ID: |
7738 |
Identification Number: |
https://doi.org/10.1002/ejoc.201301822 |
Depositing User: |
Dr. Frances Heaney
|
Date Deposited: |
13 Jan 2017 14:24 |
Journal or Publication Title: |
European Journal of Organic Chemistry |
Publisher: |
Wiley |
Refereed: |
Yes |
Funders: |
Science Foundation Ireland (SFI), Irish Research Council for Science Engineering and Technology (IRCSET) |
URI: |
|
Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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