Carty, Michael and Goodbody, Rory and Schröder, Michael and Stack, Julianne and Moynagh, Paul N. and Bowie, Andrew G. (2006) The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling. Nature Immunology, 7 (10). pp. 1074-1081. ISSN 1529-2908

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Abstract

Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor proteins containing Toll–interleukin 1 receptor (TIR) domains. Activating functions have been assigned to four TIR adaptors: MyD88, Mal, TRIF and TRAM. Here we characterize a fifth TIR adaptor, SARM, as a negative regulator of TRIF-dependent Toll-like receptor signaling. Expression of SARM blocked gene induction ‘downstream’ of TRIF but not of MyD88. SARM associated with TRIF, and ‘knockdown’ of endogenous SARM expression by interfering RNA led to enhanced TRIF-dependent cytokine and chemokine induction. Thus, the fifth mammalian TIR adaptor SARM is a negative regulator of Toll-like receptor signaling.

Item Type:	Article
Keywords:	human adaptor; SARM; adaptor protein; TRIF–dependent; Toll-like; receptor signaling;
Academic Unit:	Faculty of Science and Engineering > Biology Faculty of Science and Engineering > Research Institutes > Institute of Immunology
Item ID:	8130
Identification Number:	https://doi.org/10.1038/ni1382
Depositing User:	Professor Paul Moynagh
Date Deposited:	06 Apr 2017 15:54
Journal or Publication Title:	Nature Immunology
Publisher:	Nature Publishing Group
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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