MURAL - Maynooth University Research Archive Library

    A Plea for More Theory in Molecular Biology

    Wolkenhauer, O. and Mesarovic, M. and Wellstead, P. (2006) A Plea for More Theory in Molecular Biology. Systems Biology - Applications and Perspectives. pp. 117-138.

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    The integrationist principles of systems theory have proven hugely successful in the physical sciences and engineering. It is an underlying assumption made in the systems approach to biology that they can also be used to understand biological phenomena at the level of an entire organism or organ. Within this holistic vision, the vastmajority of systems biology research projects investigate phenomena at the level of the cell, with the belief that unifying principles established at the most basic level can establish a framework within which we may understand phenomena at higher levels of organization. In this spirit, and to use a celestial analogy, if a disease effecting an organ or entire body is our universe of discourse, then the cell is the star we gaze at. In building an understanding of disease and the effect of drugs, systems biology makes an implicit assumption about direct causal entailment between cell function and physiology. A skeptic might argue that this is about the same as trying to predict the world economy from observations made at a local supermarket. However, assuming for the moment that the money and hope we are investing inmolecular biology, genomics, and systems biology is justified, how should this amazing 118 O. Wolkenhauer, M. Mesarovi´c, P. Wellstead intellectual achievement be possible? In this chapter we argue that an essential tool to progress is a systems theory that allows biological objects and their operational characteristics to be captured in a succinct yet general form. Armed with this conceptual framework, we construct mathematical representations of standard cellular and intercellular functions which can be integrated to describe more general processes of cell complexes, and potentially entire organ.

    Item Type: Article
    Keywords: Theory; Molecular; Biology;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 943
    Depositing User: Peter Wellstead
    Date Deposited: 17 Apr 2008
    Journal or Publication Title: Systems Biology - Applications and Perspectives
    Publisher: Institute of Engineering and Technology
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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