Share and Export
Share and Export
Jones, Jennifer C., Brindley, Constance D., Elder, Nicholas H., Myers, Martin G., Rajala, Michael W., Dekaney, Christopher M., McNamee, Eóin N., Frey, Mark R., Shroyer, Noah F. and Dempsey, Peter J. (2018) Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury. Cellular and Molecular Gastroenterology and Hepatology, 7 (3). ISSN 2352-345X
Preview
EM-Cellular-2019.pdf
Download (9MB) | Preview
Abstract
Upon leucine-rich repeat-containing G-protein–coupled receptor
5–positive crypt base columnar loss, reserve stem
cell populations can repopulate the stem cell niche. This
study shows that defensin a4-Cre–expressing cells are fated
to become mature Paneth cells during normal homeostasis,
but Notch activation or doxorubicin injury causes their
dedifferentiation into multipotent stem cells.
| Item Type: | Article |
|---|---|
| Additional Information: | © 2019 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Defensin; Paneth Cell; Intestinal Stem Cells; Regeneration; Enteroid; Notch; Chemotherapy; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 10935 |
| Identification Number: | 10.1016/j.jcmgh.2018.11.004 |
| Depositing User: | Eoin McNamee |
| Date Deposited: | 11 Jul 2019 16:23 |
| Journal or Publication Title: | Cellular and Molecular Gastroenterology and Hepatology |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/10935 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
Repository Staff Only (login required)
- Item control page
Downloads
Downloads per month over past year
