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McCann, Malachy, McGinley, John, Ni, Kaijie, O'Connor, Mark, Kavanagh, Kevin, McKee, Vickie, Colleran, John, Devereux, Michael, Gathergood, Nicholas, Barron, Niall, Prisecarue, Andree and Kellett, Andrew (2013) A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction. Chemical Communications, 49 (23). pp. 2341-2343. ISSN 1359-7345
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Abstract
1,10-Phenanthroline-5,6-dione and L-tyrosine methyl ester react to form phenanthroline–oxazine (PDT) from which [Cu(PDT)2](ClO4)2 and [Ag(PDT)2]ClO4·2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)2]2+, the [Cu(PDT)2]2+ complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.
| Item Type: | Article |
|---|---|
| Keywords: | phenanthroline–oxazine ligand; synthesis; coordination chemistry; atypical DNA binding interaction; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 11105 |
| Identification Number: | 10.1039/c3cc38710k |
| Depositing User: | Dr. Kevin Kavanagh |
| Date Deposited: | 30 Sep 2019 14:10 |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemstry |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/11105 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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