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Miggin, Sinead and O'Neill, Luke A.J. (2006) New insights into the regulation of TLR signaling. Journal Of Leukocyte Biology, 80. pp. 220-226. ISSN 1938-3673
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Abstract
Toll-like receptor (TLR) activation is
dictated by a number of factors including the ligand itself and the localization of the receptor, in
terms of expression profile and subcellular localization and the signal transduction pathway that has
been activated. Recent work into TLR signal transduction has revealed complex regulation at a number of different levels including regulation by phosphorylation, targeted degradation, and sequestration of signaling molecules. Here, we describe
recent advances that have been made in our under-
standing of how TLR signaling is regulated at the
biochemical level.
| Item Type: | Article |
|---|---|
| Keywords: | inflammation; regulatory molecules; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 12629 |
| Identification Number: | 10.1189/jlb.1105672 |
| Depositing User: | Sinead Miggin |
| Date Deposited: | 26 Mar 2020 15:58 |
| Journal or Publication Title: | Journal Of Leukocyte Biology |
| Publisher: | Wiley Online Library |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/12629 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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