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    A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration


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    de Vries, Paul S., Chasman, Daniel I., Sabater-Lleal, Maria, Chen, Ming-Huei, Huffman, Jennifer E., Steri, Maristella, Tang, Weihong, Teumer, Alexander, Marioni, Riccardo E., Grossmann, Vera, Hottenga, Jouke J., Trompet, Stella, Müller-Nurasyid, Martina, Zhao, Jing Hua, Brody, Jennifer A., Kleber, Marcus E., Guo, Xiuqing, Wang, Jie Jin, Auer, Paul L., Attia, John R., Yanek, Lisa R., Ahluwalia, Tarunveer S., Lahti, Jari, Venturini, Cristina, Tanaka, Toshiko, Bielak, Lawrence F., Joshi, Peter K., Rocanin-Arjo, Ares, Kolcic, Ivana, Navarro, Pau, Rose, Lynda M., Oldmeadow, Christopher, Riess, Helene, Mazur, Johanna, Basu, Saonli, Goel, Anuj, Yang, Qiong, Ghanbari, Mohsen, Willemsen, Gonneke, Rumley, Ann, Fiorillo, Edoardo, de Craen, Anton J. M., Grotevendt, Anne, Scott, Robert, Taylor, Kent D., Delgado, Graciela E., Yao, Jie, Kifley, Annette, Kooperberg, Charles, Qayyum, Rehan, Lopez, Lorna M., Berentzen, Tina L., Räikkönen, Katri, Mangino, Massimo, Bandinelli, Stefania, Peyser, Patricia A., Wild, Sarah, Trégouët, David-Alexandre, Wright, Alan F., Marten, Jonathan, Zemunik, Tatijana, Morrison, Alanna C., Sennblad, Bengt, Tofler, Geoffrey, de Maat, Moniek P. M., de Geus, Eco J. C., Lowe, Gordon D., Zoledziewska, Magdalena, Sattar, Naveed, Binder, Harald, Völker, Uwe, Waldenberger, Melanie, Khaw, Kay-Tee, Mcknight, Barbara, Huang, Jie, Jenny, Nancy S., Holliday, Elizabeth G., Qi, Lihong, Mcevoy, Mark G., Becker, Diane M., Starr, John M., Sarin, Antti-Pekka, Hysi, Pirro G., Hernandez, Dena G., Jhun, Min A., Campbell, Harry, Hamsten, Anders, Rivadeneira, Fernando, Mcardle, Wendy L., Slagboom, P. Eline, Zeller, Tanja, Koenig, Wolfgang, Psaty, Bruce M., Haritunians, Talin, Liu, Jingmin, Palotie, Aarno, Uitterlinden, André G., Stott, David J., Hofman, Albert, Franco, Oscar H., Polasek, Ozren, Rudan, Igor, Morange, Pierre-Emmanuel, Wilson, James F., Kardia, Sharon L. R., Ferrucci, Luigi, Spector, Tim D., Eriksson, Johan G., Hansen, Torben, Deary, Ian J., Becker, Lewis C., Scott, Rodney J., Mitchell, Paul, März, Winfried, Wareham, Nick J., Peters, Annette, Greinacher, Andreas, Wild, Philipp S., Jukema, J. Wouter, Boomsma, Dorret I., Hayward, Caroline, Cucca, Francesco, Tracy, Russell, Watkins, Hugh, Reiner, Alex P., Folsom, Aaron R., Ridker, Paul M., O'Donnell, Christopher J., Smith, Nicholas L., Strachan, David P. and Dehghan, Abbas (2015) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25 (2). pp. 358-370. ISSN 0964-6906

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    Abstract

    Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
    Item Type: Article
    Keywords: Ameta-analysis; 120 246 individuals; identifies; 18 new loci; fibrinogen concentration;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17197
    Identification Number: 10.1093/hmg/ddv454
    Depositing User: Lorna Lopez
    Date Deposited: 17 May 2023 10:16
    Journal or Publication Title: Human Molecular Genetics
    Publisher: Oxford University Press
    Refereed: Yes
    Related URLs:
    URI: https://mural.maynoothuniversity.ie/id/eprint/17197
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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