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    A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function


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    McCarthy, Mark I., Porcu, Eleonora, Medici, Marco, Pistis, Giorgio, Volpato, Claudia B., Wilson, Scott G., Cappola, Anne R., Bos, Steffan D., Deelen, Joris, den Heijer, Martin, Freathy, Rachel M., Lahti, Jari, Liu, Chunyu, Lopez, Lorna M., Nolte, Ilja M., O'Connell, Jeffrey R., Tanaka, Toshiko, Trompet, Stella, Arnold, Alice, Bandinelli, Stefania, Beekman, Marian, Böhringer, Stefan, Brown, Suzanne J., Buckley, Brendan M., Camaschella, Clara, de Craen, Anton J. M., Davies, Gail, de Visser, Marieke C. H., Ford, Ian, Forsen, Tom, Frayling, Timothy M., Fugazzola, Laura, Gögele, Martin, Hattersley, Andrew T., Hermus, Ad R., Hofman, Albert, Houwing-Duistermaat, Jeanine J., Jensen, Richard A., Kajantie, Eero, Kloppenburg, Margreet, Lim, Ee M., Masciullo, Corrado, Mariotti, Stefano, Minelli, Cosetta, Mitchell, Braxton D., Nagaraja, Ramaiah, Netea-Maier, Romana T., Palotie, Aarno, Persani, Luca, Piras, Maria G., Psaty, Bruce M., Räikkönen, Katri, Richards, J. Brent, Rivadeneira, Fernando, Sala, Cinzia, Sabra, Mona M., Sattar, Naveed, Shields, Beverley M., Soranzo, Nicole, Starr, John M., Stott, David J., Sweep, Fred C. G. J., Usala, Gianluca, van der Klauw, Melanie M., van Heemst, Diana, van Mullem, Alies, H.Vermeulen, Sita, Visser, W. Edward, Walsh, John P., Westendorp, Rudi G. J., Widen, Elisabeth, Zhai, Guangju, Cucca, Francesco, Deary, Ian J., Eriksson, Johan G., Ferrucci, Luigi, Fox, Caroline S., Jukema, J. Wouter, Kiemeney, Lambertus A., Pramstaller, Peter P., Schlessinger, David, Shuldiner, Alan R., Slagboom, Eline P., Uitterlinden, André G., Vaidya, Bijay, Visser, Theo J., Wolffenbuttel, Bruce H. R., Meulenbelt, Ingrid, Rotter, Jerome I., Spector, Tim D., Hicks, Andrew A., Toniolo, Daniela, Sanna, Serena, Peeters, Robin P. and Naitza, Silvia (2013) A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function. PLoS Genetics, 9 (2). e1003266. ISSN 1553-7404

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    Abstract

    Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span. In addition, even mild alterations in thyroid function are associated with weight changes, atrial fibrillation, osteoporosis, and psychiatric disorders. To identify novel variants underlying thyroid function, we performed a large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4, in up to 26,420 and 17,520 euthyroid subjects, respectively. Here we report 26 independent associations, including several novel loci for TSH (PDE10A, VEGFA, IGFBP5, NFIA, SOX9, PRDM11, FGF7, INSR, ABO, MIR1179, NRG1, MBIP, ITPK1, SASH1, GLIS3) and FT4 (LHX3, FOXE1, AADAT, NETO1/FBXO15, LPCAT2/CAPNS2). Notably, only limited overlap was detected between TSH and FT4 associated signals, in spite of the feedback regulation of their circulating levels by the hypothalamic-pituitary-thyroid axis. Five of the reported loci (PDE8B, PDE10A, MAF/LOC440389, NETO1/FBXO15, and LPCAT2/CAPNS2) show strong gender-specific differences, which offer clues for the known sexual dimorphism in thyroid function and related pathologies. Importantly, the TSH-associated loci contribute not only to variation within the normal range, but also to TSH values outside the reference range, suggesting that they may be involved in thyroid dysfunction. Overall, our findings explain, respectively, 5.64% and 2.30% of total TSH and FT4 trait variance, and they improve the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism.
    Item Type: Article
    Keywords: Meta-Analysis; Thyroid-Related; Traits; Reveals; Novel Loci; Gender-Specific Differences; Regulation; Thyroid Function;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17257
    Identification Number: 10.1371/journal.pgen.1003266
    Depositing User: Lorna Lopez
    Date Deposited: 29 May 2023 16:01
    Journal or Publication Title: PLoS Genetics
    Publisher: Public Library of Science
    Refereed: Yes
    Related URLs:
    URI: https://mural.maynoothuniversity.ie/id/eprint/17257
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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