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    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations


    Köttgen, Anna, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M, Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D, Kutalik, Zoltán, Smith, Albert V, Shi, Julia, Struchalin, Maksim, Middelberg, Rita P S, Brown, Morris J, Gaffo, Angelo L, Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F, Liu, Xuan, Malerba, Giovanni, Lopez, Lorna M., van der Harst, Pim, Li, Xinzhong, Kleber, Marcus E, Hicks, Andrew A, Nolte, Ilja M, Johansson, Asa, Murgia, Federico, Wild, Sarah H, Bakker, Stephan J L, Peden, John F, Dehghan, Abbas, Steri, Maristella, Tenesa, Albert, Lagou, Vasiliki, Salo, Perttu, Mangino, Massimo, Rose, Lynda M, Lehtimäki, Terho, Woodward, Owen M, Okada, Yukinori, Tin, Adrienne, Müller, Christian, Oldmeadow, Christopher, Putku, Margus, Czamara, Darina, Kraft, Peter, Frogheri, Laura, Thun, Gian Andri, Grotevendt, Anne, Gislason, Gauti Kjartan, Harris, Tamara B, Launer, Lenore J, McArdle, Patrick, Shuldiner, Alan R, Boerwinkle, Eric, Coresh, Josef, Schmidt, Helena, Schallert, Michael, Martin, Nicholas G, Montgomery, Grant W, Kubo, Michiaki, Nakamura, Yusuke, Tanaka, Toshihiro, Munroe, Patricia B, Samani, Nilesh J, Jacobs, David R, Liu, Kiang, D'Adamo, Pio, Ulivi, Sheila, Rotter, Jerome I, Psaty, Bruce M, Vollenweider, Peter, Waeber, Gerard, Campbell, Susan, Devuyst, Olivier, Navarro, Pau, Kolcic, Ivana, Hastie, Nicholas, Balkau, Beverley, Froguel, Philippe, Esko, Tõnu, Salumets, Andres, Khaw, Kay Tee, Langenberg, Claudia, Wareham, Nicholas J, Isaacs, Aaron, Kraja, Aldi, Zhang, Qunyuan, Wild, Philipp S, Scott, Rodney J, Holliday, Elizabeth G, Org, Elin, Viigimaa, Margus, Bandinelli, Stefania, Metter, Jeffrey E, Lupo, Antonio, Trabetti, Elisabetta, Sorice, Rossella, Döring, Angela, Lattka, Eva, Strauch, Konstantin, Theis, Fabian, Waldenberger, Melanie, Wichmann, H-Erich, Davies, Gail, Gow, Alan J, Bruinenberg, Marcel, Stolk, Ronald P, Kooner, Jaspal S, Zhang, Weihua, Winkelmann, Bernhard R, Boehm, Bernhard O, Lucae, Susanne, Penninx, Brenda W, Smit, Johannes H, Curhan, Gary, Mudgal, Poorva, Plenge, Robert M, Portas, Laura, Persico, Ivana, Kirin, Mirna, Wilson, James F, Leach, Irene Mateo, van Gilst, Wiek H, Goel, Anuj, Ongen, Halit, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, Andre G, Imboden, Medea, von Eckardstein, Arnold, Cucca, Francesco, Nagaraja, Ramaiah, Piras, Maria Grazia, Nauck, Matthias, Schurmann, Claudia, Budde, Kathrin, Ernst, Florian, Farrington, Susan M, Theodoratou, Evropi, Prokopenko, Inga, Stumvoll, Michael, Jula, Antti, Perola, Markus, Salomaa, Veikko, Shin, So-Youn, Spector, Tim D, Sala, Cinzia, Ridker, Paul M, Kähönen, Mika, Viikari, Jorma, Hengstenberg, Christian, Nelson, Christopher P, Meschia, James F, Nalls, Michael A, Sharma, Pankaj, Singleton, Andrew B, Kamatani, Naoyuki, Zeller, Tanja, Burnier, Michel, Attia, John, Laan, Maris, Klopp, Norman, Hillege, Hans L, Kloiber, Stefan, Choi, Hyon, Pirastu, Mario, Tore, Silvia, Probst-Hensch, Nicole M, Völzke, Henry, Gudnason, Vilmundur, Parsa, Afshin, Schmidt, Reinhold, Whitfield, John B, Fornage, Myriam, Gasparini, Paolo, Siscovick, David S, Polašek, Ozren, Campbell, Harry, Rudan, Igor, Bouatia-Naji, Nabila, Metspalu, Andres, Loos, Ruth J F, van Duijn, Cornelia M, Borecki, Ingrid B, Ferrucci, Luigi, Gambaro, Giovanni, Deary, Ian J, Wolffenbuttel, Bruce H R, Chambers, John C, März, Winfried, Pramstaller, Peter P, Snieder, Harold, Gyllensten, Ulf, Wright, Alan F, Navis, Gerjan, Watkins, Hugh, Witteman, Jacqueline C M, Sanna, Serena, Schipf, Sabine, Dunlop, Malcolm G, Tönjes, Anke, Ripatti, Samuli, Soranzo, Nicole, Toniolo, Daniela, Chasman, Daniel I, Raitakari, Olli, Kao, W H Linda, Ciullo, Marina, Fox, Caroline S, Caulfield, Mark, Bochud, Murielle and Gieger, Christian (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45 (2). pp. 145-154. ISSN 1061-4036

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    Abstract

    Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
    Item Type: Article
    Keywords: genome-wide; association; analyses; identify; 18 new loci; serum urate concentrations;
    Academic Unit: Faculty of Science and Engineering > Biology
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 17315
    Identification Number: 10.1038/ng.2500
    Depositing User: Lorna Lopez
    Date Deposited: 14 Jun 2023 11:26
    Journal or Publication Title: Nature Genetics
    Publisher: Nature Research
    Refereed: Yes
    Related URLs:
    URI: https://mural.maynoothuniversity.ie/id/eprint/17315
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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