Bronfenbrenner's ecological (and later bioecological) theory has been a mainstay in the theoretical wheelhouse of developmental and family sciences since its inception in the 1970s. However, few studies accurately operationalize Bronfenbrenner's process-person-context-time (PPCT) research model. The aim of this paper is to provide a practical guide to the design, implementation, and analysis of PPCT research studies. Using recent qualitative and quantitative publications from developmental and family science journals, we illustrate how his theory can be operationalized simply and effectively in 21st-century research. The eight studies, three qualitative and five quantitative, feature participants from Chile, China, South Africa, Turkey, and the United States.