Share and Export
Share and Export
Moynagh, Paul N. (2009) The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends in Immunology, 30 (1). pp. 33-42. ISSN 1471-4906
Preview
PM_pellino family 2009.pdf
Download (1MB) | Preview
Abstract
This review highlights the emerging roles of the Pellino family of E3 ubiquitin ligases as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. The functional importance of the Pellino family as RING-like-domain-containing proteins with intrinsic ubiquitin E3 ligase activity that can catalyse polyubiquitylation of the key TLR signalling molecule IRAK1 is discussed in detail. The importance of Pellino proteins as novel targets for mediating negative regulation of TLR signalling is also explored. This new knowledge and understanding of Pellino biology begins to fill some long-standing voids in our understanding of TLR signalling.
| Item Type: | Article |
|---|---|
| Additional Information: | The definitive published version of this article is available at DOI: 10.1016/j.it.2008.10.001 |
| Keywords: | Pellino family; IRAK E3 ligases; innate immune signalling; toll-like receptor pathways; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 7199 |
| Identification Number: | 10.1016/j.it.2008.10.001 |
| Depositing User: | Professor Paul Moynagh |
| Date Deposited: | 18 Jul 2016 15:57 |
| Journal or Publication Title: | Trends in Immunology |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Funders: | Science Foundation Ireland (SFI) |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/7199 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
Repository Staff Only (login required)
- Item control page
Downloads
Downloads per month over past year
