Connor, Gregory (2016) Adjusted p-values for genome-wide regression analysis with non-normally distributed quantitative phenotypes. Working Paper. Department of Economics, Finance & Accounting Working Paper N274-16. (Unpublished)
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Abstract
This paper provides a small-sample adjustment for Bonferonni-corrected p-values in multiple univariate regressions of a quantitative
phenotype (such as a social trait) on individual genome markers. The
p-value estimator conventionally used in existing genome-wide association (GWA) regressions assumes a normally-distributed dependent
variable, or relies on a central limit theorem based approximation.
We show that the central limit theorem approximation is unreliable
for GWA regression Bonferonni-corrected p-values except in very large
samples. We note that measured phenotypes (particularly in the case
of social traits) often have markedly non-normal distributions. We
propose a mixed normal distribution to better fit observed phenotypic variables, and derive exact small-sample p-values for the standard GWA regression under this distributional assumption.
Item Type: | Monograph (Working Paper) |
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Keywords: | Adjusted p-values; genome; regression analysis; quantitative phenotypes; |
Academic Unit: | Faculty of Social Sciences > Economics, Finance and Accounting |
Item ID: | 7473 |
Depositing User: | Ms Sandra Doherty |
Date Deposited: | 28 Sep 2016 15:37 |
Publisher: | Department of Economics, Finance & Accounting Working Paper N274-16 |
URI: | https://mural.maynoothuniversity.ie/id/eprint/7473 |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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