2022

Dyck, Lydia and Prendeville, Hannah and Raverdeau, Mathilde and Wilk, Mieszko M. and Loftus, Roisin M. and Douglas, Aaron and McCormack, Janet and Moran, Bruce and Wilkinson, Michael and Mills, Evanna L. and Doughty, Michael and Fabre, Aurelie and Heneghan, Helen and LeRoux, Carel and Hogan, Andrew E. and Chouchani, Edward T. and O’Shea, Donal and Brennan, Donal and Lynch, Lydia (2022) Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Journal of Experimental Medicine, 219 (3). ISSN 0022-1007

2019

O'Brien, Aisling and Loftus, Roisin M. and Pisarska, Marta M. and Tobin, Laura M. and Bergin, Ronan and Wood, Nicole A.W. and Foley, Cathriona and Mat, Arimin and Tinley, Frances C. and Bannan, Ciaran and Sommerville, Gary and Veerapen, Natacha and Besra, Gurdyal S. and Sinclair, Linda V. and Moynagh, Paul N. and Lynch, Lydia and Finlay, David K. and O'Shea, Donal and Hogan, Andrew (2019) Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. Journal of Immunology, 202. pp. 3404-3411. ISSN 0022-1767

2018

Harmon, Cathal and Robinson, Mark W. and Hand, Fiona and Almuaili, Dalal and Mentor, Keno and Houlihan, Diarmaid D. and Hoti, Emir and Lynch, Lydia and Geoghegan, Justin and O'Farrelly, Cliona (2018) Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of LiverResident NK Cells in Colorectal Liver Metastasis. Cancer Immunology Research, 7 (2). p. 2018. ISSN 2326-6066

Michelet, Xavier and Dyck, Lydia and Hogan, Andrew and Loftus, Roisin and Duquette, Danielle and Wei, Kevin and Beyaz, Semir and Tavakkoli, Ali and Foley, Cathriona and Donnelly, Raymond and O'Farrelly, Cliona and Raverdeau, Mathilde and Veron, Ashley and Pettee, William and O'Shea, Donal and Nikolajczyk, Barbara S and Mills, Kingston H.G. and Brenner, Michael B. and Finlay, David and Lynch, Lydia (2018) Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nature Immunology, 19. pp. 1330-1340. ISSN 1529-2908

2017

Boulenouar, Selma and Michelet, Xavier and Duquette, Danielle and Alvarez, Daniel and Hogan, Andrew and Dold, Christina and O’Connor, Donal and Stutte, Suzanne and Tavakkoli, Ali and Winters, Desmond and Exley, Mark A. and O'Shea, Donal and Brenner, Michael B. and von Andrian, Ulrich and Lynch, Lydia (2017) Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity, 46 (2). pp. 273-286. ISSN 1097-4180

2016

Lynch, Lydia and Hogan, Andrew and Duquette, Danielle and O'Shea, Donal and Brenner, Michael B. (2016) iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metabolism, 24. pp. 510-519. ISSN 1550-4131

2015

Carolan, Eirin and Tobin, Laura M. and Mangan, Bozgana A. and Corrigan, Michelle and Gaoatswe, Gadintshware and Byrne, Greg and Geoghegan, Justin and Cody, Declan and O'Connell, Jean and Winter, Desmond C and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal and Hogan, Andrew (2015) Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity. Journal of Immunology, 194 (12). pp. 5775-5780. ISSN 0022-1767

2014

Hogan, Andrew and Gaoatswe, Gadintshware and Lynch, Lydia and Corrigan, Michelle and Woods, Conor and O'Connell, Jean and O'Shea, Donal (2014) Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia, 57. pp. 781-784. ISSN 0012-186X

2012

Lynch, Lydia and Nowak, Michael and Varghese, Bindu and Clark, Justice and Hogan, Andrew and Toxavidis, Vasillis and Balk, Steven P. and O'Shea, Donal and O'Farrelly, Cliona and Exley, Mark A. (2012) Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production. Immunity, 37 (3). pp. 574-587. ISSN 1097-4180

2011

Hogan, Andrew and Corrigan, Michelle and O'Reilly, Vincent P. and Gaoatswe, G. and O'Connell, Jean and Doherty, Derek G. and Lynch, Lydia and O'Shea, Donal (2011) Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clinical Immunology, 140. pp. 229-235. ISSN 1521-6616

Hogan, Andrew and Tobin, A.M. and Ahern, T. and Corrigan, Michelle and Gaoatswe, Gadintshware and Jackson, Ruaidhri and O’Reilly, Vincent P. and Lynch, Lydia and Doherty, D.G. and Moynagh, Paul N. and Kirby, B. and O’Connell, Jean and O'Shea, Donal (2011) Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer Tcells: lessons from obesity, diabetes and psoriasis. Diabetologia, 54 (11). pp. 2745-2754. ISSN 0012-186X