McCann, Malachy and McGinley, John and Ni, Kaijie and O'Connor, Mark and Kavanagh, Kevin and McKee, Vickie and Colleran, John and Devereux, Michael and Gathergood, Nicholas and Barron, Niall and Prisecarue, Andree and Kellett, Andrew (2013) A new phenanthroline–oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction. Chemical Communications, 49 (23). pp. 2341-2343. ISSN 1359-7345

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Abstract

1,10-Phenanthroline-5,6-dione and L-tyrosine methyl ester react to form phenanthroline–oxazine (PDT) from which [Cu(PDT)2](ClO4)2 and [Ag(PDT)2]ClO4·2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen)2]2+, the [Cu(PDT)2]2+ complex does not cleave DNA in the presence of added reductant indicating unique interaction with DNA.

Item Type:	Article
Keywords:	phenanthroline–oxazine ligand; synthesis; coordination chemistry; atypical DNA binding interaction;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	11105
Identification Number:	https://doi.org/10.1039/c3cc38710k
Depositing User:	Dr. Kevin Kavanagh
Date Deposited:	30 Sep 2019 14:10
Journal or Publication Title:	Chemical Communications
Publisher:	Royal Society of Chemstry
Refereed:	Yes
URI:	https://pubs.rsc.org/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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