Martin, Harlei and McGovern, Mairead and Abbey, Lorna and Gilroy, Aisling and Mullins, Stephanie and Howell, Sarah and Kavanagh, Kevin and Velasco-Torrijos, Trinidad (2018) Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates. European Journal of Medicinal Chemistry, 160. pp. 82-93. ISSN 0223-5234

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Abstract

The yeast Candida albicans is an opportunistic fungal pathogen which induces superficial and systemic infections in immunocompromised patients. Adherence to host tissue is critical to its ability to colonise and infect the host. The work presented here describes the synthesis of a small library of aromatic glycoconjugates (AGCs) and their evaluation as inhibitors of C. albicans adherence to exfoliated buccal epithelial cells (BECs). We identified a divalent galactoside, ligand 2a, capable of displacing over 50% of yeast cells already attached to the BECs. Fluorescence imaging indicates that 2a may bind to structural components of the fungal cell wall.

Item Type:	Article
Keywords:	Candida albicans; Anti-Adherence; Multivalent glycoconjugates; Structure-activity relationship study; Copper-catalyzed azide-alkyne cycloaddition (CuAAC);
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	12436
Identification Number:	https://doi.org/10.1016/j.ejmech.2018.10.011
Depositing User:	Dr. Trinidad Velasco-Torrijos
Date Deposited:	17 Feb 2020 16:44
Journal or Publication Title:	European Journal of Medicinal Chemistry
Publisher:	Elsevier
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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